CAS2627-69-2, AICAR (Acadesine)

AMPK is a key protein in metabolic regulation. When energy supply is insufficient, AMP/ATP ratio is up-regulated, and AMPK is activated to inhibit anabolism. AICAR activates AMPK, but does not affect ATP, ADP, and AMP levels. At the cellular or animal level, AICAR can promote non-insulin-dependent glucose intake by activating AMPK in skeletal muscle. AICAR induced skeletal muscle glucose intake cannot be blocked by inhibitors of PI3K.

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